Senior consultant, Institute of Infectious Diseases and Epidemiology (IIDE), Tan Tock Seng Hospital
Yong Loo Lin School of Medicine, National University of Singapore
Lee Kong Chian School of Medicine, Nanyang Technological University
Principal investigator, Singapore Infectious Disease Clinical Research Network (SCRN)

Professor Lye was a co-principal investigator in STOP-dengue translational clinical research programme (2008-2014) which focused on the control, treatment and prevention of adult dengue. Highlights from clinical research in STOP-dengue included a large retrospective cohort of adult dengue from 2005 to 2008 (“ARDENT”) and a prospective adult dengue study (PADS) from 2010 to 2012, which have provided a lot of insights into the management of adult dengue especially among the elderly. A randomised clinical trial of prophylactic platelet transfusion for adult dengue patients with thrombocytopenia (ADEPT) was completed.

As the lead for SCRN, Professor Lye is involved in randomised clinical trials to optimise antibiotic use in the era of antibiotic resistance. A-KLASS is a clinical trial of oral versus intravenous antibiotics to treat Klebsiella liver abscess. MERINO and MERINO-2 are two clinical trials studying carbapenem-sparing therapy for E coli and K pneumoniae bacteraemia with extended spectrum beta-lactamases, and gram negative bacteraemia with chromosomal AmpC producers respectively, in collaboration with Australasian Society for Infectious Diseases Clinical Research Network (ASID CRN). Funded via Late Phase Clinical Trial Grant, CAMERA-2 is a clinical trial in collaboration with ASID CRN on better ways of treating methicillin-resistant S aureus bacteraemia.

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